We are exploring a new therapeutic approach for Parkinson’s disease by targeting the Gucy2c receptor, which could help restore dopamine levels and protect neurons without side effects. To develop a highly specific peptide-ligand, we will combine rational design with advanced computational methods. We are looking for a motivated post-doc with a strong background in computational chemistry to join our multidisciplinary team in Amsterdam and London. This project offers an exciting opportunity to contribute to innovative research in a collaborative environment.
Join our project!
Parkinson’s disease (PD) is the most prevalent neurological disorder after Alzheimer’s pathology. Physical symptoms, such as the inability to move, are caused by the progressive degeneration of dopamine neurons located in the substantia-nigra. There is currently no cure for PD nor is there a long-term effective treatment.
In our quest to find novel therapeutic approaches to treat PD we have identified the Gucy2c receptor as a potential target. This receptor is specifically expressed in the substantia nigra. This receptor improves clinical symptoms comparable to levodopa in an animal PD model whereas complementary studies have shown that the Gucy2c receptor also protects dopamine neurons against toxic insults and cell death. Due to its specific expression, therapeutically targeting Gucy2c would have no side-effects, restore dopamine levels and prevent further neurodegeneration. Here we aim to develop a potent and highly specific Gucy2c peptide-ligand. To achieve this, we will combine rational design with a computationally-based active learning workflow.
What you will do
You are expected to:
- work in a multidisciplinary team at the University of Amsterdam and University College London (both expected to be 6 months);
- to design novel peptide ligands for the Gucy2c receptor using computational chemistry and rational design;
- identify the most optimal novel ligands by a novel computational active learning;
- to report and present your work-progress on a regular basis to the research partners and stakeholders within this project;
- participate actively in the fundamental research of the computational chemistry team;
- participate actively in the development and application of both physics-based and AI methodologies, individually and in combination,
- for the selection of novel small molecules or peptides with potential pharmaceutical applications.
What we look for
You have:
- a PhD degree in physics, chemistry or a related discipline complemented by computational chemistry skills;
- a strong background in (bio)chemistry; demonstrated experience with molecular dynamics simulations (ensemble methods, enhanced sampling, NAMD code, advanced analysis etc.) or the motivation to learn;
- proven record of the ability to conduct high quality research, which is evidenced in the authorship of quality publications in an area relevant to the project;
- good working knowledge in an area of drug development, personalized medicine, artificial intelligence or a relevant field and of using high performance computers;
- excellent programming skills;
- excellent communication skills in oral and written English;
- strong initiative and good time management skills.
Our selection will be based on your scientific track record, your vision on this research project, and your ambition and skills. As this Amsterdam project will partly be conducted in the UK we expect willingness to frequently travel abroad.
What we offer you
We offer a temporary contract for 38 hours a week for the duration of 12 months. The salary, depending on relevant experience before the beginning of the employment contract, will be between €3.345 - €5.278 gross per month, based on a fulltime contract (38 hours a week). This is exclusive 8% holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable. Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.
