About your role
- You will perform multiparameter immune phenotyping of bone marrow aspirates and peripheral blood samples to deepen our insights into how immune dysfunction negatively affects immunotherapy outcomes in multiple myeloma. You will focus on novel T cell immunotherapies such as CAR T cell therapy and T cell redirecting bispecific and trispecific antibodies. A better understanding of resistance mechanisms may lead to novel strategies to improve efficacy of immunotherapy.
- You will set up and execute advanced techniques including spectral flow cytometry, imaging mass - cytometry (IMC/Image CyTOF) and spatial genomics on bone marrow samples to deepen our understanding of TME and therapy outcomes.
- You will conduct functional immunological assays to deepen our insights into immune exhaustion and senescence, and evaluate novel strategies to enhance efficacy of immunotherapy by mitigating immune dysfunction or immunosuppressive components in TME.
- You will collaborate with a multidisciplinary team of immunologists, hematologists, and bioinformaticians.
- You will present findings at internal and external scientific meetings.
About you- You hold a PhD in immunology, tumor biology, or a related field.
- You have strong expertise in tumor immunology.
- You have demonstrated affinity for advanced immune profiling techniques and functional immune assays.
- Experience with high-dimensional data analysis is a plus.
- You have excellent communication and collaborative skills. You are fluent in English, both written and spoken.
Our offer- A flying start to your career in scientific research.
- Plenty of room for your drive to shape tomorrow's healthcare.
- Working on large-scale and in-house research, with motivated colleagues from all over the world.
- You will be employed by Amsterdam UMC Research BV.
- A contract for 12 months, with the intention to extend for a total of 4 or 5 years.
- Salary scale 10: € 3.598 to € 5.669 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
- Holiday hours: 190.4 per year for fulltime and a possibility to save additional hours.
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
- For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
- Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.
Watch this video with more information about joining Amsterdam UMC Research BV.
