PhD student biological testing of novel COPD treatment

University Medical Center Groningen (UMCG) • Internship • Groningen • €3.11k - €3.94k / year • 3w ago

Patients with COPD often emphysema coinciding with air being trapped in the lungs, preventing efficient breathing. An effective treatment is implanting one-way valves in the lungs to remove the trapped air. Although efficient, the body often reacts to these foreign devices, leading to excessive inflammation and fibrosis. In order to reduce these detrimental side-effects, we will develop a new anti-fouling coating for these valves that prevent cells, proteins and micro-organisms from binding to the valves, ultimately preventing the detrimental host response. The PhD student will be responsible for testing biocompatibility and functional effects of these novel coatings using various advanced lab techniques. The PhD student needs to be a biomedical scientist with some affinity for material science. Within this project a wide range of lab techniques will be used, including (primary) human lung cell culture, Organ-on-Chip development, microscopy, immunohistochemistry, qRT-PCR and ELISA. The PhD student will need to independently set-up and perform in vitro experiments. Moreover, the student needs to disseminate the results by writing scientific articles and giving presentations at (international) conferences. Collaboration is very important in this project, therefore the student needs to be pro-active and have excellent communicative skills. Additionally, as in vitro model development is part of the project the student needs to be creative, handy and have technical skills.

- You have a Master’s degree in Molecular/Medical Biology, Biomedical Sciences, or equivalent. - You are aware of, and can comply with, requirements for working within a confidential research collaboration. - You have expertise with cell culture, and you have a VMT certificate or equivalent. - You have experience with immunological, cell and molecular biological techniques such as RNA isolation, qPCR, ELISA, immunohistochemistry. - You have excellent organizational, communication and interaction skills. - Command of the English language in spoken and written word is mandatory.

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