Join us!

We are looking for an enthusiastic PhD student to work on a research project funded by KWF Kankerbestrijding, which aims to investigate if and how the WNT/CTNNB1 pathway is a target for therapeutic intervention in breast cancer. Are you looking for a basic biomedical research project with clear clinical relevance? Do you want to understand how cancer cells can hijack a developmental signalling pathway? Do you like a challenge? Then this might be the chance to satisfy your curiosity.

This is what you will do

We have identified a complex biomarker (i.e. a multi-gene signature) that allows us to stratify breast cancer patients with different levels of WNT/CTNNB1 pathway activity. In the first half of the project, you will work in close collaboration with a bioinformatician (to be recruited) to further improve the specificity of our current gene signature. In the second half of the project, you will obtain proof-of-principle for the therapeutic intervention through WNT/CTNNB1 pathway modulation, both in vitro (using breast cancer cell lines) and in vivo (using patient derived xenografts).

Tasks and responsibilities:

Complete and defend a PhD thesis within the official appointment duration of four years;
Use multiple state-of-the-art experimental approaches to measure and manipulate WNT/CTNNB1 signalling (including mammalian cell culture, various molecular and cell biology techniques, CUT&RUN, RNA-seq, and PDX studies in mice);
Perform your experiments in a systematic and well controlled manner;
Keep accurate records by thoroughly documenting and organising your work;
Stay on top of the relevant scientific literature;
Discuss your work in our lab meetings, incorporate feedback and give input to others;
Assist in teaching and supervise BSc/MSc students during their research internship;
Participate in the Faculty of Science PhD training programme.

You will get the opportunity to

Learn a wide variety of experimental and data analysis techniques;
Build a network as part of our (inter)national collaborations;
Present your work at (inter)national meetings;
Continuously hone your academic, professional and personal skills;
Contribute to the science communication and outreach activities of the lab.

What we ask of you

You work well independently but are also willing to contribute to team efforts. You are a nice colleague with good communication skills. You use your organizational skills to ensure efficient planning and project management, enabling you to meet deadlines. Your work shows that you pay attention to detail, but you also have eye for the bigger conceptual picture. You draw on your critical thinking and problem-solving skills when needed.

Your experience and profile:

a recent MSc degree in the biomedical sciences (or a related area);
a strong interest in developmental, stem cell and cancer biology;
affinity with WNT signaling and mammary gland biology;
affinity with gene regulation and chromatin biology;
a strong intrinsic motivation and aptitude for fundamental research (reflected by your training record);
an Art. 9 qualification (or the willingness to become Art. 9 qualified);
willingness to work with mice;
willingness to supervise BSc and/or MSc students during their internship;
fluent in English, both written and spoken.

If you are genuinely excited about this project and are willing and able to learn, then we offer you the environment to do so. However, it will work to your advantage if you already have some (hands-on) experience with one or more of the following: bioinformatics analyses (e.g. R, Python), mammalian cell culture, DNA cloning, CUT&RUN or ChIPseq, mouse handling, histology analyses.

This is what we offer you

A temporary contract for 38 hours per week for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of 4 years). The preferred starting date is June or July 2026. This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.

Based on a full-time appointment (38 hours per week) the gross monthly salary will range from €3.059 in the first year to €3.881 (scale P) in the last year. This does not include 8% holiday allowance and 8,3% year-end allowance. The UFO profile PhD candidate is applicable. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Universities of the Netherlands is applicable.

Curious about our extensive secondary benefits package? You can read more about it here.

You will work in this team

The Faculty of Science has a student body of around 8,000, as well as 1,800 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.

The Swammerdam Institute for Life Sciences (SILS) is located at the vibrant Amsterdam Science Park. SILS is one of eight institutes of the University of Amsterdam's Faculty of Science (FNWI). With around 240 employees, SILS carries out internationally high-quality life science research and provides education within various university programs. Research is also carried out in close cooperation with the medical, biotech, chemical, flavor, food & agricultural, and high-tech industries, and revolves around 4 main themes, Cell & Systems biology, Neurosciences, Microbiology and Green Life Sciences.

You will be embedded in the Developmental, Stem Cell and Cancer Biology group, led by prof.dr. Renée van Amerongen (who will also act as your primary/daily supervisor). Research in our group aims to understand how complex tissues are built and maintained. We study this at multiple different levels – “from man or mouse to molecule” – using a variety of experimental approaches and with a specific focus on developmental signaling pathways in the context of breast (cancer) biology and early embryonic development. In this project, we will closely collaborate with the group of prof.dr. Jos Jonkers at the Netherlands Cancer Institute (including a secondment in his lab). The CUT&RUN experiments are done in close collaboration with the lab of Dr. Claudio Cantu (including a short research visit to Sweden).

Do you want to develop new personalized treatment solutions for breast cancer?

Join us!

This is what you will do

Tasks and responsibilities:

Complete and defend a PhD thesis within the official appointment duration of four years;
Use multiple state-of-the-art experimental approaches to measure and manipulate WNT/CTNNB1 signalling (including mammalian cell culture, various molecular and cell biology techniques, CUT&RUN, RNA-seq, and PDX studies in mice);
Perform your experiments in a systematic and well controlled manner;
Keep accurate records by thoroughly documenting and organising your work;
Stay on top of the relevant scientific literature;
Discuss your work in our lab meetings, incorporate feedback and give input to others;
Assist in teaching and supervise BSc/MSc students during their research internship;
Participate in the Faculty of Science PhD training programme.

You will get the opportunity to

Learn a wide variety of experimental and data analysis techniques;
Build a network as part of our (inter)national collaborations;
Present your work at (inter)national meetings;
Continuously hone your academic, professional and personal skills;
Contribute to the science communication and outreach activities of the lab.

What we ask of you

Your experience and profile:

a recent MSc degree in the biomedical sciences (or a related area);
a strong interest in developmental, stem cell and cancer biology;
affinity with WNT signaling and mammary gland biology;
affinity with gene regulation and chromatin biology;
a strong intrinsic motivation and aptitude for fundamental research (reflected by your training record);
an Art. 9 qualification (or the willingness to become Art. 9 qualified);
willingness to work with mice;
willingness to supervise BSc and/or MSc students during their internship;
fluent in English, both written and spoken.

This is what we offer you

Curious about our extensive secondary benefits package? You can read more about it here.

You will work in this team

If you feel the profile fits you, and you are interested in the job, we look forward to receiving your application. You can apply online via the button below. We accept applications until and including 5 April 2026.

If you have any questions or do you require additional information? Please contact:

Prof.dr. Renée van Amerongen, hoogleraar fundamenteel stamcel- en kankeronderzoek
r.vanamerongen@uva.nl
T: +31 0205255682

Applications should include the following information (all files besides your cv should be submitted in one single pdf file):

a detailed CV including the months (not just years) when referring to your education and work experience;

a letter of motivation;

the names and email addresses of two references who can be contacted

Interviews and selection are tentatively scheduled to take place between 20 April and 9 May 2026, but we may start processing applications before that time.

A knowledge security check can be part of the selection procedure.
(for details: national knowledge security guidelines)

Only complete applications received within the response period via the link below will be considered.

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