PhD (f/m/d) Structural Biology of Inflammation

The Faculty of Medicine is one of the four founding faculties of the Eberhard Karls University of Tübingen. With its non-clinical facilities as well as its research and teaching area corresponding to the organisational units of the University Hospital, it is one of the largest medical training and research institutions in Baden-Württemberg.

Within our Department of Medical Oncology and Pneumology & Cluster of Excellence „Image-guided and Functionally Instructed Tumor Therapies“ (iFIT) we are looking for a

PhD (f/m/d) Structural Biology of Inflammation

in parttime (65 %) and limited for 2 years with further extension expected.

Inflammation is the first-line defence protecting out bodies against various infections and damages. However, dysregulated due to mutations, environmental factors or life style, inflammation does more bad than good. Indeed, chronic inflammation stands behind such pathologies as diabetes, cardiovascular diseases, neurodegeneration, cancer and many other diseases of the modern-day society. The Andreeva lab focuses on structural and functional aspects of inflammatory pathways underlying these pathologies. By using a combination of structural, biochemical and cell-based approaches we aim to comprehensively explain inflammatory pathways from molecular to cellular level, which is crucial for clinical applications and development of novel anti-inflammatory treatments, as well as next generation cancer diagnostics and therapeutics, which are the main goal of the iFIT Cluster of Excellence „Image Guided and Functionally Instructed Tumor Therapies (iFIT)“ consortium, which we are part of.

Further reading:
https://www.cell.com/cell/fulltext/S0092-8674(21)01326-X
https://www.nature.com/articles/nature23890
https://www.nature.com/articles/s41586-019-1295-z

Your Tasks:

• Perform molecular biology techniques (cloning, mutagenesis) and recombinant protein expression with purification methods
• Conduct protein biochemistry assays (SDS-PAGE, Western Blotting, fluorescence / activity assays) and cryo-EM workflows (grid preparation, data collection, model building)
• Execute cell culture and cell-based assays, including stable cell line generation and viability testing
• Analyze experimental data and interpret results for scientific reporting
• Write and present scientific findings clearly and effectively

Your Profile:

• Diploma or Master’s degree (or equivalent) in molecular biology, biochemistry, life sciences or a related discipline
• Hands-on experience in molecular / cellular biology and protein biochemistry
• Experience in structural biology is desirable
• Strong interest in structural biology and immunity
• Excellent organization and communication skills
• Fluency in English (written and spoken)

Further information:
We are a young group working on exciting projects in a highly dynamic, relevant and rapidly developing field. We are looking for like-minded to do excellent science in a vibrant and collaborative atmosphere at one of the top universities in Germany.

Application is open now! A complete application contains a short cover letter (max. 1 A4 page), a CV, transcripts and certificates for both your MSc and BSc degrees and contact details for 1-2 references. Please submit all documents as a single PDF file. Both German and international applications are encouraged. Applications will be reviewed on an ongoing basis and interviews scheduled accordingly.

We offer remuneration in accordance with TV-L (collective wage agreement for the Public Service of the German Federal States), severely handicapped persons with equal qualifications are given preferential consideration. Interview expenses are not covered. Please note the applicable vaccination regulations.

Your application:
We are looking forward to your online application to Ms. Dr. Liudmila Andreeva including CV and cover letter under specification of the index number 5236.

If you have any questions, please contact:
Ms. Dr. Liudmila Andreeva
+49 7071 29-86773

Closing date for applications: 26.11.2024