Postdoctoral Researcher

MRC Postdoctoral Research Scientist

Functional Gene Control group (PI: Dr Mikhail Spivakov)

Salary: £41,344 plus London allowances (£5,385) per annum

(3 Year fixed term)

London, UK

Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

We combine wet-lab and computational approaches to study how enhancers, enhancer-promoter contacts and cis-regulatory networks mediate the effects of disease-linked genetic variants and extracellular signals on gene expression.

We are looking for a creative, self-motivated and collaborative postdoctoral scientist with either a wet-lab and/or computational background.

For a computational scientist, we expect sound experience of applying, and ideally developing, advanced statistical and AI approaches to epigenomics data arising from single-cell and bulk assays, and a confident knowledge of genomics data manipulation in R/python.

For a wet-lab scientist, we expect strong experience in applying and troubleshooting high-throughput epigenomics and/or CRISPR targeting (activation/interference) assays in application to mammalian stem or immune cells, and ideally a track record of successful methodology development. Some computational experience in genomic data analysis is desirable.

The ideal candidates will have the willingness and track record to apply for personal postdoctoral fellowships in the first year of their stay with us.

Functional Gene Control group led by Dr Mikhail Spivakov is a friendly, close-knit and enthusiastic interdisciplinary team based in the Epigenetics section of MRC LMS. For more information, see the group’s websites at http://functionalgenecontrol.group/ and https://lms.mrc.ac.uk/research-group/functional-gene-control/.

Keywords: regulatory genomics, enhancers, CRISPR perturbation assays, chromosomal conformation analysis, machine learning, gene regulation.

The post is an MRC Postdoctoral Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field. We offer a highly attractive benefits package including a competitive salary, excellent holiday entitlement, and a generous pension scheme.

For full details of this post and to complete an online application, visitMRC Postdoctoral Research Scientist LMS 2584 - Medical Research Council and upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number: LMS 2584

Closing date: 21/04/2025

Final appointment will be subject to pre-employment screening.

Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs for applicant (100% visa and 100% Health Surcharge) and immediate dependents (100% visa and 50% health surcharge when applying with main applicant) can be reclaimed from LMS after taking up the post (terms and conditions apply).