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    • London

Ansök senast: 2025-04-22

Research Assistant or Associate in Therapeutic Expression

Publicerad 2025-02-21

A Research Associate is sought to work on the expression of therapeutic proteins and vaccines in the yeast Pichia pastoris with particular emphasis on virus-like particles and monoclonal antibodies. The post is part of the UKRI-funded Engineering Biology Mission Hub GlycoCell.


The project will involve strain engineering, small-scale production and purification of proteins in bioreactors, and the characterisation of their quality (assembly state, glycosylation, etc). 


The following essential knowledge, skills & experience are sought:

  • PhD in life sciences, bioengineering, (bio)chemical engineering, biotechnology or a closely related discipline, or equivalent research, industrial or commercial experience*
  • Practical experience in a broad range of techniques including Pichia pastoris engineering (genetic construct design, transformation, colony selection)
  • Practical experience in protein characterisation assays, particularly in the determination of virus-like particle assembly (electron microscopy, dynamic light scattering)
  • Knowledge of Pichia pastoris metabolism
  • Experience of working in a multidisciplinary team
  • The following knowledge, skills & experience is also desirable:

  • Practical experience with cell-free protein synthesis to predict in vivo expression levels of candidate proteins
  • Practical experience with small-scale fermentation using bioreactors

  • The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
  • Grow your career: gain access to Imperial’s sector-leading as well as opportunities for promotion and progression.
  • Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).
  • Be part of a diverse, inclusive and collaborative work culture with various and resources to support your personal and professional .
  • Liknande jobb

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