Research Assistant or Associate in Therapeutic Expression
<p>Social network you want to login/join with:</p><h3>Research Assistant or Associate in Therapeutic Expression, London</h3><p>Client: Imperial College London</p><p>Location: London, United Kingdom</p><p>Job Category: Other</p><p>EU work permit required: Yes</p><h3>Job Reference:</h3><p>0bd6d4dd447b</p><h3>Job Views:</h3><p>6</p><h3>Posted:</h3><p>11.03.2025</p><h3>Expiry Date:</h3><p>25.04.2025</p><h3>Job Description:</h3><p>A Research Associate is sought to work on the expression of therapeutic proteins and vaccines in the yeast Pichia pastoris with particular emphasis on virus-like particles and monoclonal antibodies. The post is part of the UKRI-funded Engineering Biology Mission Hub GlycoCell.</p><p>The project will involve strain engineering, small-scale production and purification of proteins in bioreactors, and the characterisation of their quality (assembly state, glycosylation, etc).</p><h3>Essential Knowledge, Skills & Experience:</h3><ul><li>PhD in life sciences, bioengineering, (bio)chemical engineering, biotechnology or a closely related discipline, or equivalent research, industrial or commercial experience</li><li>Practical experience in a broad range of techniques including Pichia pastoris engineering (genetic construct design, transformation, colony selection)</li><li>Practical experience in protein characterisation assays, particularly in the determination of virus-like particle assembly (electron microscopy, dynamic light scattering)</li><li>Knowledge of Pichia pastoris metabolism</li><li>Experience of working in a multidisciplinary team</li></ul><h3>Desirable Knowledge, Skills & Experience:</h3><ul><li>Practical experience with cell-free protein synthesis to predict in vivo expression levels of candidate proteins</li><li>Practical experience with small-scale fermentation using bioreactors</li></ul><p>The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity. Grow your career: gain access to Imperial’s sector-leading as well as opportunities for promotion and progression. Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes). Be part of a diverse, inclusive and collaborative work culture with various resources to support your personal and professional development.</p>
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