Research Associate in biochemical neuroscience and dementia - London

Research Associate in biochemical neuroscience and dementia Job Type: Full-Time. Starting Salary: 48056 plus benefits To find out more about the job please click the ‘apply for job’ button to be taken to Imperial job site Job summary The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Postdoctoral Research Associate (PDRA) position leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Parkinsons disease and how removal of such aggregates may be enhanced as a therapeutic strategy for disease intervention. The project will investigate proteostasis systems in post-mortem donor samples and quantify the effect of aggregate load on IPSC-derived neurons. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to unveil the mechansism of proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates. This research will be driven in close collaboration with our industry partner Eisai. This role is part of the Department of Brain Sciences at Imperial College London , located in. Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with: Access to a range of cutting-edge technologies for 2D and 3D super-resolution imaging capabilities Dedicated iPSC culture facilities in the new state-of-the-art Sir Michael Uren Hub. A collegial, team-oriented working environment. Follow us on Instagram National links with colleagues in the UK DRI at Imperial and Eisai. Support from the Postdoc and Fellows Development Centre ( PFDC ) and Imperial and UK DRI ECR Communities The opportunity to mentor, supervise and teach students Duties and responsibilities As a Research Associate in the Ye lab, you will: Build on your existing skills and experience to address major components of this project independently. Present research findings as written reports, at conferences, within the College and as published manuscripts. Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers. Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students. Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required. Maintain highly organised and accurate records of experimental work. Undertake appropriate scientific and professional training. Essential requirements You are a motivated and organised researcher , excited by the science we do. With (or near completion of) a PhD in Cellular/Molecular Neuroscience with experience with IPSC cultures or in Neuropathology of Dementia (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively. Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus. Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab. Further information This position is offered fixed term on a full or part time basis for up to two-years. Please contact Dr Yu Ye - yu.ye1imperial.ac.uk for a discussion about the project and role. Appointments are typically made to the first spine point of the scale. Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range. Candidates will need to complete an online application; CVs alone will not be accepted. The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/ The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the Colleges care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research /