Snabbfakta
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- London
Ansök senast: 2024-12-03
Research Associate in biochemical neuroscience and dementia
The invite applications from talented, highly motivated, and ambitious scientists up to two Postdoctoral Research Associate (PDRA) positions leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Parkinson’s disease and Alzheimer’s disease, and how aggregate removal may be enhanced as a therapeutic strategy for disease intervention. We have up to two vacancies leading the research in pathological protein aggregates containing alpha-synuclein or tau and how they may be degraded in model neurons. Therefore, experience in molecular neuroscience, protein aggregation or IPSC work is vital for these projects. The projects will study proteostasis systems in post-mortem donor samples and quantify the effect of aggregate load on IPSC-differentiated neurons. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to investigate proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates. After successful interviews, the panel will recommend appointment to projects funded by Alzheimer’s Research UK or Eisai depending on suitability. The Parkinson’s disease project will be driven in close collaboration with our industry partner at Eisai.
Interested candidates should contact Dr Yu Ye –
at , located in Sir Michael Uren Hub, White City Campus. Postdocs in the Ye lab at Imperial enjoy excellent career development opportunities with:
As a Research Associate in the Ye lab, you will:
You are a motivated and organised researcher, excited by the science we do.
With (or near completion of) a PhD in Cellular/Molecular Neuroscience with experience in protein aggregation, IPSC cultures or in Neuropathology of Dementia (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.
Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus.
Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab.
This position is offered fixed term on a full or part time basis for up to two-years.
