Oncogenesis Stress Signaling (OSS)

The OSS laboratory is a translational research structure bringing together biologists and clinicians to better understand oncogenesis in brain and gynecological cancers. By associating biologists working on cancer stress signaling pathways and cancer clinicians, the laboratory aims at deciphering how tumor cells cope with stresses to resist to death. Moreover, OSS researchers collaborate with chemists for the design and synthesis of novel pharmacological molecules that target the relevant stress signaling pathways.
TEAM 1Death Receptors & Tumor Escape (DR@TE)The Team aims at 1) showing how CD95 switches from implementing cell death to non-apoptotic signaling pathways, 2) characterizing the cells whose function is deregulated by the naturally processed ligand in breast cancers and 3) generating with chemists original inhibitors of the CD95-mediated non-apoptotic signaling pathways.
TEAM 2Proteostasis and Cancer (PROSAC)Maintaining protein homeostasis also named proteostasis is important in the normal ‘housekeeping’ of the body and of the cells and plays a critical role in cancer. The PROSAC team focuses on Endoplasmic Reticulum proteostasis control in cancer and on the role of the SUMO/Ubiquitin interplay in the DNA damage response.