About your role
You will work at the interface of computational method development, pipeline engineering, and translational cancer research, with a focus on understanding therapy resistance in acute myeloid leukemia (AML).
Your tasks include:
- developing, optimizing, and maintaining reproducible computational pipelines for single-cell long-read data (e.g. improving or extending tools such as FLAMES or related frameworks);
- designing analytical strategies to genotype individual cells and study clonal dynamics in longitudinal AML samples;
- integrating single-cell multi-omics datasets, including scRNA-seq, scATAC-seq and CITE-seq to study mechanisms of therapy resistance;
- ensuring pipelines are robust, well-documented, and accessible for other researchers;
- translating complex datasets into biological insights in collaboration with experimental scientists.
About youYou are a computational scientist with a strong interest in biology and enjoy working in a collaborative research environment. You combine technical expertise with analytical thinking and clear communication.
You bring:
- a PhD (or near completion) in bioinformatics, computational biology, computer science, statistics, or a related field;
- strong programming skills in Python and/or R;
- experience with single-cell genomics data analysis, such as scRNA-seq, scATAC-seq or multiome data;
- experience with workflow management systems (e.g. Nextflow, Snakemake or WDL) and version control (Git);
- strong communication, presentation, and scientific writing skills, and the ability to work both independently and collaboratively.
Experience with long-read sequencing, isoform analysis, variant calling, or scalable computing environments is considered an advantage.
Our offer- A flying start to your career in scientific research.
- Plenty of room for your drive to shape tomorrow's healthcare.
- Working on large-scale and in-house research, with motivated colleagues from all over the world.
- You will be employed by Amsterdam UMC Research BV.
- A contract for 12 months, with the intention to extend for the duration of the project.
- Salary scale 10: € 3.598 tot € 5.669 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
- Holiday hours: 190,4 per year for fulltime and a possibility to save additional hours.
- Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
- 100% reimbursement for public transport travel costs. If you travel by foot, bicycle, or car, a mileage allowance of €0.21 per km applies (up to a maximum of 40 km one way by car).
Watch this video with more information about joining Amsterdam UMC Research BV.
