Snabbfakta
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- Sutton
Ansök senast: 2024-08-13
Clinical Research Fellow (PhD)
Under the leadership ofNavita Somaiah and Jörg Mansfeld, we are seeking to appoint a Clinical Research Fellow to undertake a fully funded translational PhD project entitled:
Exploiting the full potential of hydrogen peroxide as a cancer therapeutic via reverse translation
The proposed research follows a bed-to-bench approach utilising patient data and samples from the KORTUC trial to inform functional and mechanistic experiments in mice and breast cancer cell lines. Further information can be found in the job description pack.Key Requirements
The successful candidate must have a clinical oncology/radiation oncology/medical oncology background
Department/Directorate Information
1. Translational Breast Radiobiology Group, Division of Radiotherapy and Imaging https://www.icr.ac.uk/our-research/researchers-and-teams/dr-navita-somaiahDr Navita Somaiah is a group leader (clinician scientist) at The Institute of Cancer Research, London, and an honorary clinical oncology consultant at The Royal Marsden. Her team work on optimisation of radiotherapy by improving tumour response whilst minimising normal tissue toxicity for more personalised treatments.
The division also includes the prestigious Cancer Research UK Cancer Imaging Centre, and overlaps with the Joint Department of Physics, which spans The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust. Researchers in the division are interested in developing ways of increasing the effectiveness of radiotherapy by combining it with other treatments – including targeted drugs. A major research focus is the development of multimodality imaging for evaluating response to treatment in vivo. Novel imaging techniques can provide non-invasive assessments of various facets of tumour biology such as tumour angiogenesis, cell proliferation and hypoxia.
2. Post-translational Modification Group, Division of Cancer Biology https://www.icr.ac.uk/our-research/researchers-and-teams/dr-joerg-mansfeld
Dr Jörg Mansfeld is a group leader in the Cancer Biology Division of The Institute of Cancer Research, London. His Post-translationa lModifications and Proliferation Team investigates how the redox system regulates the cellular decision “to proliferate or not to proliferate” with anemphasis on breast cancer. To this end they apply cutting edge cell biological and biochemical approaches such as CRISPR/Cas9-mediated genome engineering, quantitative light microscopy, and in vitro reconstitution assays to determine how protein oxidation by reactive oxygen species regulates protein function and cellular signalling. The team works closely together with other teams across the ICR to harness their mechanistic findings for future cancer treatments.
3. Centre for Genome Stability at the ICR and The Royal Marsden
https://www.icr.ac.uk/our-research/centres-and-collaborations/centres-at-the-icr/centre-for-genome-stability-research-and-translation
Centre for Genome Stability (CGS) is a unique multidisciplinary programme bringing together experts from across the ICR and The Royal Marsden who work on DNA-damage response and genome instability research with clinical experts in the treatment of cancer. This PhD fellowship is funded via the MRC Doctoral Training Programme award.Fler jobb från Talent
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