Snabbfakta
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- Paris
Ansök senast: 2024-10-28
PhD IN IMMUNOLOGY (CIFRE) (M/ F)
About us
The Institut Curie Research Center
The Institut Curie is a major player in cancer research, with a strong interdisciplinary tradition. It comprises a hospital and a research center with over 1,000 staff and a strong international presence, and is located in the heart of Paris, France, in a rich cultural and scientific environment.
The aim of the Institut Curie Research Center is to develop basic research and use the knowledge generated to improve cancer diagnosis, prognosis and treatment, as part of the continuum between basic research and innovation in the service of patients. The site has an active seminar program and regularly hosts training sessions in molecular and cellular biology.
Mission
Laboratory
The project will be developed within the Cancer Immunotherapy Center at the Immunology Department (INSERM Unit U932), headed by Ana-Maria Lennon. Unit U932 comprises 10 independent research teams in fundamental and applied immunology, working in a highly collaborative and international environment.
The candidate will work under the supervision of Dr Hélène Salmon, who heads the “Stroma and Immunity” team within U932, as part of a CIFRE thesis with Sanofi. The team's main objective is to decipher the dialogue between stromal cells, particularly fibroblasts, and immune cells in cancer. Based on recent work identifying fibroblast subpopulations (CAF - cancer associated fibroblasts) associated with T-cell exclusion in lung cancer (Grout et al, Cancer Discovery 2022), the team aims to decipher the mechanisms underlying the control of T-cell distribution by CAF. Ultimately, the projects aim to develop new strategies to specifically target the stromal compartment in tumor lesions and improve clinical responses to conventional therapies.
Missions
Dr. Hélène Salmon's team is looking for a candidate for a Thesis in Immunology studying the targeting of cancer-associated fibroblasts to promote T cell infiltration and anti-tumor cytotoxicity in lung cancer. The position is part of a CIFRE Thesis grant. The candidate will be dedicated to:
- Exploring human tumor lesions by combining multiplex imaging and spatial transcriptomics to identify CAF-specific genes involved in T-cell exclusion.
- Test the effects of these CAF targets on T cell dynamics and tumor lysis using CRISPR and a human tumor spheroid/CAF system developed in the lab.
- Evaluate in preclinical models the therapeutic potential of therapies targeting fibroblasts and checkpoint blockade.
Profile
- M2 in immunology, molecular and cellular biology, or biotechnology
- Culture of primary cells and tumor cell lines
- Flow cytometry
- French (professional) required
- Animal experimentation
- Knowledge of human immunology, oncology and immunotherapy
- Scientific rigor and excellent analytical and synthesis skills
- Team spirit and dynamic personality with a passion for innovation and problem-solving
Experience in image analysis (ImageJ, Halo, etc.), transcriptomic analysis (RNA sequencing), or molecular biology (cloning) would be appreciated.
All our opportunities are open to people with disabilities
Contract information
Type of contract: PhD CIFRE contract of 3 years
Starting date: as soon as possible
Duration: 3 years
Working time: full time
Remuneration: according to the current grids
Benefits: collective catering
Location of the position: Paris, 26 rue d’Ulm
Reference: NA
Contact
Please send your CV, letter of motivation, email contact for 2 references
Publication date: 29th August 2024
Deadline for application: until candidate is found
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
