Snabbfakta
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- Cambridge
Ansök senast: 2024-12-19
PhD Studentship: Synthetic Organic Chemistry/ Chemical Biology
Applications are invited for a 4-year PhD studentship based in the Department of Chemistry, University of Cambridge and the new AstraZeneca Discovery Centre at Cambridge. The student will be working on a collaborative project jointly supervised by Prof David Spring (Cambridge) and Dr Jonathan Bargh (AstraZeneca) and will have opportunity to work across the two sites.
The project will combine the advances in Antibody-Drug Conjugates (ADCs) with antisense oligonucleotides. ADCs have revolutionized targeted cancer therapy by delivering cytotoxic drugs to cancer cells with reduced systemic toxicity. Concurrently, oligonucleotide-based therapies, such as antisense oligonucleotides, have expanded the therapeutic landscape, offering novel approaches for modulating gene expression and protein function. Antibody-Oligonucleotide Conjugates (AOCs) combine the specificity of antibodies with the gene-modulating capabilities of oligonucleotides. This research aims to develop a novel method for conjugating oligonucleotides to antibodies, utilizing divinylpyridine motifs. The project will involve both organic synthesis and chemical biology skills.
We are looking for a highly motivated and enthusiastic individual capable of thinking and working independently. Applicants must have (or expect to obtain) at least the equivalent of a UK upper second-class Master's degree in a relevant subject such as Chemistry. Ideally, the candidate will have a strong background in organic chemistry. Practical experience of synthetic organic chemistry and peptide chemistry in a research environment would be beneficial.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
