Postdoctoral fellowship in ultrasensitive nano(bio)sensing

All optical and label free biomolecularly-resolved nanosizing platforms based on single particle observations: Join our interdisciplinary team at the VU to develop record-breaking next-generation instruments.

Job description

Drug formulations are increasingly composed of so-called "nanodrugs", precisely controlled containers that target-specifically deliver complex molecules such as DNAs or RNAs. Surprisingly, much-needed nano characterization platforms that rapidly, quantitatively and accurately asses the quality of such formulations are still lacking. Routine observations are often based on costly options such as TEM or analytical ultracentrifugation.

During this 30 months postdoctoral fellowship, you will develop an all-optical and label-free single particle sizing platform that rapidly measures thousands of individual nanoparticles in parallel. The clear and ambitious goal is to provide a technology that covers the full range of nanodrugs: from tiny viral vectors, over bacteriophages to larger liposomes. You will provide what is needed: size, mass, loading ratios e.g. a full characterization of these crucial system based on all-optical single particle observations.

Beyond accurately determining particle sizes and drug-loading ratios you will develop next-generation methods that directly quantify the biomolecular composition. The envisioned strategy is novel which ensures that you will have the chance to establish a highly innovative sensing-portfolio that should allow applying for competitive funding beyond this appointment.

With the support of our interdisciplinary team, you will lead this ambitious project and:

• Develop high-throughput nanosizing methods at the ultimate levels of sensitivity and accuracy
• Apply these platforms to prominent nanometric drug vectors
• Help transitioning our technology into a widely applicable and usable platform
• Explore and implement biomolecularly resolved nanosizing technologies

Requirements

The ideal candidate will have a strong background in experimental nanophotonics, all-optical sensing or label-free microscopy.

• PhD degree in Chemistry, Physics or Nanotechnology
• Experience with designing and building optical instrumentation (microscopy) is a must
• Experience with label-free or holographic imaging/sensing of single nano-objects is a bonus
• Experience with programming and hardware-software interfacing is a plus
• Excellent written and oral communication skills
• Excited about interdisciplinary research as part of multidisciplinary and diverse team
• Strong interpersonal skills and the ability to collaboratively work with other researchers
• Eager to learn and apply new skills

Conditions of employment

Fixed-term contract: 1 year.

A fully funded one year postdoctoral fellowship with ample room for personal development in a socially engaged organisation. We offer:

• A salary of minimum € 3.345,00 (Scale 10) and maximum € 4.185,00 (Scale 10.5) gross per month, on a full-time basis. This is based on UFO profile Researcher 4. The exact salary depends on your education and experience.
• The appointment will initially be for 1 year. Subject to a positive evaluation, the contract will be extended for a total duration of 30 months.
• Plenty of room to acquire new skills to develop a highly-competitive research portfolio.

We also offer you attractive fringe benefits and regulations. Some examples:

• a full-time 38-hour working week comes with a holiday leave entitlement of 232 hours per year. If you choose to work 40 hours, you have 96 extra holiday leave hours on an annual basis. For part-timers, this is calculated pro rata.
• 8% holiday allowance and 8.3% end-of-year bonus
• contribution to commuting expenses
• space for personal development
• a wide range of sports facilities which staff may use at a modest charge

Employer

Vrije Universiteit Amsterdam

The MatzLab develops next-generation imaging and sensing platforms in the context of future biomedical, pharmaceutical, and clinical applications. We are particularly interested in label-free or digital approaches, where we combine fundamental research with systematic platform and assay development. To realise our vision, we build on an interdisciplinary toolbox comprising molecular biology, ultrafast optics, advanced microscopy, and nanophotonics, with the key ingredient being creativity and room for personal development.

Faculty of Science
Researchers and students at VU Amsterdam’s Faculty of Science tackle fundamental and complex scientific problems to help pave the way for a sustainable and healthy future. From forest fires to big data, from obesity to malnutrition, and from molecules to the moon: we cover the full spectrum of the natural sciences. Our teaching and research have a strong experimentally technical, computational and interdisciplinary nature.

We work on new solutions guided by value-driven, interdisciplinary methodologies. We are committed to research, valorisation and training socially engaged citizens of the world who will make valuable contributions to a sustainable, healthy future.

Are you interested in joining the Faculty of Science? You will join undergraduate students, PhD candidates and researchers at the biggest sciences faculty in the Netherlands. You will combine a professional focus with a broad view of the world. We are proud of our collegial working climate, characterised by committed staff, a pragmatic attitude and engagement in the larger whole. The faculty is home to over 11,000 students enrolled in 40 study programmes. It employs over 1,600 professionals spread across 10 academic departments.

Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam stands for values-driven education and research. We are open-minded experts with the ability to think freely. - a broader mind. Maintaining an entrepreneurial perspective and concentrating on diversity, significance and humanity, we work on sustainable solutions with social impact. By joining forces, across the boundaries of disciplines, we work towards a better world for people and planet. Together we create a safe and respectful working and study climate, and an inspiring environment for education and research. Learn more about our codes of conduct

We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 5,500 staff work at the VU and over 30,000 students attend academic education.

Diversity
Diversity is the driving force of the VU. The VU wants to be accessible and receptive to diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences and worldviews. We believe that trust, respect, interest and differences lead to new insights and innovation, to sharpness and clarity, to excellence and a broader understanding.

We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services.

Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community.

Additional information

We look forward to receiving your online application with the following documents as a single PDF:

• A cover letter describing your current research interests
• A CV including list of publications
• A list ranking your experience with microscopy; holographic microscopy/imaging; nanophotonics; nonlinear optics; designing optical instrumentation; programming. (0-10 scale, with 0 = no experience, 10 = world leading expert)
• Contact details of at least two references

Evaluation will be done on a rolling basis until the vacancy is filled.

Applications received by e-mail will not be considered.

Acquisition in response to this advertisement is not appreciated.