Snabbfakta
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- Oxford
Ansök senast: 2024-07-30
Postdoctoral Research Associate in Statistical Genomics
Publicerad 2024-05-31
We are seeking
to appoint a Postdoctoral Research Associate to join the Germline Genomics laboratory led by Dr Anjali Hinch at the Sir William Dunn School of Pathology, University of Oxford. The laboratory uses a combination of statistical, computational, and experimental approaches to understand how processes in our cells lead to changes in their DNA. These changes include errors (mutations) or shuffling up of chromosomes (recombination) in human eggs and sperm, which lead to genetic alterations that may be inherited by future generations. We investigate the mechanisms underlying these changes and their impacts on our health and the evolution of species. Furthermore, we leverage them to understand how mutations arise in cancers. For example, in our work published recently in Science, we show that many mutations, a much higher number than previously thought, are the result of deliberate self-induced damage in our cells. This leads to mutations in 1 in 4 sperm and 1 in 12 eggs and increases the risk of many diseases, including developmental disorders and cancer. In this role, you will work on the development of statistical models and machine learning algorithms and their application to large-scale datasets of human genetic variation, chromatin and epigenetic maps, protein binding data, and disease traits. You will lead your research and have opportunities for international collaborations and for presenting your work at international conferences and workshops.
