Snabbfakta
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- London
Ansök senast: 2024-12-02
Research Associate and Scientific Coordinator
How do cancers evade immune destruction and what is the basis for immunotherapy sensitivity? We are studying these questions using a unique human cancer model (gestational trophoblastic neoplasia - GTN), along with tissues from common human cancers and mice models.
We seek an energetic and creative immunologist for a CRUK funded postdoctoral position until 31-March-2028. The project is based with Dr. Ehsan Ghorani at Imperial College London. Collaborators include Prof. Lucy Walker at the UCL Institute of Immunity and Transplantation, Prof. Sergio Quezada at the UCL Cancer Institute and Prof. Rafi Ahmed at the Emory Vaccine Center.
GTN is a rare cancer arising from placental trophoblasts and is:
Studying these paradoxes will shed light on mechanisms of immune regulation in other cancers.
We have unique access to GTN samples through the world’s largest clinic at Imperial and will validate key concepts using samples from common cancers (lung and renal) we are collecting from two large UK immunotherapy clinical trials (REFINE-Lung and REFINE).
You will lead work characterising the immune response to GTN with a focus on CD4 T cells using a systems immunology approach including use of single cell methods, TCR sequencing, multiplex immunofluorescence, explant culture and functional experiments. You will have bioinformatics support, access to state of the art facilities in a vibrant and supportive environment and ample opportunities for career development.
Suitable candidates should hold or about to hold a PhD in immunology of cancer, transplantation, autoimmunity, reproduction or a related area, a strong track record and a passion for researching and understanding the immune system in cancer.
