Snabbfakta
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- Manchester
Ansök senast: 2024-09-13
Research Associate in Ice Binding Protein-Inspired Polymer Synthesis
The postholder will work as a Research Associate in the group of Prof Matthew Ian Gibson in the Department of Chemistry at the University of Manchester. For more information about the Gibson group and their research interests, please visit the group website (). This role is focussed on the chemical synthesis of next generation ice-binding polymers, to mimic ice binding, and ice-nucleating proteins. We use these across a range of cryopreservation but also biotechnological application areas. For example, we have developed polymers ( J. Am. Chem. Soc, 2018, 140, 5682 ) and nanoparticles ( J. Am. Chem. Soc, 2021. 143, 7449 ) which can modulate ice formation. See our review for applications: Nature Reviews Chemistry, 2022, 6, 579
The GibsonGroup has world-class facilities based in both the Department of Chemistry (where this role is primarily based) and also in the Manchester Institute of Biotechnology (MIB). The Chemistry laboratories are brand new (2023) featuring dedicated write up space, fume hoods, and analytical equipment including UV-Vis, FTIR (and in 2024) NMR spectrometers, microscopes and liquid handling systems. For polymer analysis we have a multidetector SEC suite, as well as the departments core NMR and Mass Spec facilities. We access the UKs National Materials Institute, the Royce, which is in an adjacent building. In the MIB we have dedicated tissue culture and microbiology laboratories and a bioanalytical suite including biolayer interferometry, flow cytometry, high-content live cell microscopy and (in 2024) confocal microscopy. From 2025 the team will host a UK unique automated glycan synthesis platform.
The GibsonGroup is a positive research environment, and the successful candidate is expected to contribute to the groups research culture, focussed on team work.
The project will involve the synthesis and characterization of advanced polymers and polymer nanoparticles, which can impact cryobiological processes. This will also involve polymer/protein bioconjugation. This will involve a range of controlled polymerization techniques, particularly RAFT, but ring opening polymerization may be used. There will also be significant (bio) analytical measurements undertaken to include cryo-microscopy, for which the team has its own dedicated platform. The PDRA will report directly to Professor Matthew I. Gibson. A strong research and publication track record is essential with demonstrated ability to lead and finish (including publishing) projects. You must have excellent communication, presentation, interpersonal and teamworking skills.
What you will get in return:
